Faced with urgent needs due to conflicts and the growing number of soldiers and civilians suffering from severe burns, scientists from Tel Aviv University (TAU) and Sheba Tel Hashomer Medical Center have successfully developed a unique bio-engineered artificial skin for grafting to burn victims.
According to a VNA reporter in Tel Aviv, this breakthrough technology is completely created from the patient's own cells, is highly stable, easy to manipulate and flexible.
This artificial skin speeds up the recovery process, healing wounds twice as fast as current methods and could radically change the way severe burns are treated.
“No skin has ever been created like this before and we have seen very promising results,” said Professor Lihi Adler-Abramovich, research leader from TAU’s Laboratory of Bioinspired Materials and Nanotechnology.
The team quickly combined expertise in chemistry, medicine and clinical care to advance the research shortly after the conflict between Israel and the Islamist Hamas movement broke out in October 2023.
Traditional burn treatments often rely on grafting healthy skin from another area of the patient's body. However, in cases of extensive burns, patients often do not have enough healthy skin left to perform the procedure.
Another method currently used in Israel is to culture skin in the laboratory from a small biopsy, but this method is time-consuming and only regenerates the surface layer of skin.
The new technology is based on a manufacturing technique called electrospinning, in which microscopic fibers are woven into fabric-like sheets. This technique creates a nanofiber scaffold—a structure that can regenerate or repair damaged skin. The scaffold has a super-fine mesh structure, with fibers thousands of times thinner than a human hair.
Professor Adler-Abramovich, a member of the research team and an expert in peptide nanotechnology, said she incorporated a “very short peptide chain” into the fibre scaffold: “Peptides are chains of amino acids – the building blocks of proteins. We used a chain of three amino acids that mimics the natural sequence found in the human body.”
She added that the design of the fiber scaffold combined with the peptide was the breakthrough of the project. This structure helps the cells adhere well, stimulates growth and effectively regenerates the skin. It is both durable and easy to implant.
The team has filed a patent for the fiber scaffold — which is said to be the first design to combine electrospinning, FDA-approved polymers, and bioactive peptides.
“We saw better-looking scar tissue,” says Professor Adler-Abramovich. “The skin appeared to function normally. Wound healing was much faster, which shortened the patient’s hospital stay and reduced the risk of infection. We even saw hair follicle growth.”
The field of artificial skin care is growing rapidly. A start-up in the city of Lod, Israel, Nanomedic Technologies Ltd., is also developing a medical device that uses similar technology to cover burns and wounds with artificial skin.
Regarding future prospects, Prof. Adler-Abramovich said it will take several years to call for funding for large animal testing, after which clinical research on humans can be conducted./.
Source: https://www.vietnamplus.vn/israel-phat-trien-da-nhan-tao-sinh-hoc-giup-dieu-tri-bong-nang-post1049654.vnp
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